Recurrent presence of the PLCG1 S345F mutation in nodal peripheral T-cell lymphomas.
نویسندگان
چکیده
Rebeca Manso,1# Socorro M. Rodríguez-Pinilla,1# Julia González-Rincón,2 Sagrario Gómez,2 Silvia Monsalvo,3 Pilar Llamas,3 Federico Rojo,1 David Pérez-Callejo,2 Laura Cereceda,4 Miguel A. Limeres,5 Carmen Maeso,6 Lucía Ferrando,7 Carlos Pérez-Seoane,8 Guillermo Rodríguez,8 José M. Arrinda,9 Federico García-Bragado,10 Renato Franco,11 José L. Rodriguez-Peralto,12 Joaquin González-Carreró,13 Francisco MartínDávila,14 Miguel A. Piris,4* and Margarita Sánchez-Beato2*
منابع مشابه
Immunophenotyping of Nodal Peripheral T-cell Lymphomas and its Association with Epstein-Barr Virus
Background: Immunophenotyping in the rare group of nodal Peripheral T-cell Lymphomas (PTCL) exposes interesting features such as T-cell marker downregulation and paradoxically, the presence of reactive, clustered large-sized CD20 positive B-cells (B-cell proliferation). Epstein-Barr virus (EBV) has been suggested as a putative etiology in pathogenesis of B-cell lymphoma. We aimed to review the ...
متن کاملPLCG1 mutations in cutaneous T-cell lymphomas.
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of primary cutaneous T-cell lymphoproliferative processes, mainly composed of mycosis fungoides and Sézary syndrome, the aggressive forms of which lack an effective treatment. The molecular pathogenesis of CTCL is largely unknown, although neoplastic cells show increased signaling from T-cell receptors (TCRs). DNAs from 11 patients with ...
متن کاملPeripheral T-cell Lymphoma of the Uvula: A Rare Entity
Abstract Introduction: Extra-nodal exposition of T-cell non-hodgkin lymphoma (NHL) is extremely rare, and is frequently observed in patients with immune system dysfunction. Peripheral T-cell lymphoma does not express CD56 is rare. Malignant lymphoma of the uvula is exceedingly unusual. The current study reported a case of peripheral T-cell lymphoma of the uvula in an immunecompetent patient. ...
متن کاملPeripheral T-cell Lymphoma of the Uvula: A Rare Entity
Abstract Introduction: Extra-nodal exposition of T-cell non-hodgkin lymphoma (NHL) is extremely rare, and is frequently observed in patients with immune system dysfunction. Peripheral T-cell lymphoma does not express CD56 is rare. Malignant lymphoma of the uvula is exceedingly unusual. The current study reported a case of peripheral T-cell lymphoma of the uvula in an immunecompetent patient. ...
متن کاملNodal peripheral T-cell lymphoma with secondary granulomatous cutaneous involvement.
Sir, The presence of a granulomatous pattern has rarely been described in cutaneous lymphomas, mycosis fungoides (MF) being the variant more frequently reported (1 – 4). The aetiology of granulomatous reactions remains unclear and its prognostic value is still disputed, although a favourable influence on outcome has been hypothesized (5). We report here the case of an 87-year-old man with nodal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Haematologica
دوره 100 1 شماره
صفحات -
تاریخ انتشار 2015